The other day I was trying to make sense of all my feeds, that is, keeping up with the enormous amount of unread news, and I saw an article on IBM DeveloperWorks, "Weaving a better web page".
Turns out this is a very useful concept. Abstracting away browser differences (Internet Explorer, anyone?), layout and typography are the main areas where these kind of frameworks shine. The one mentioned in the article is Blueprint, but there's tons of others, like yaml.
When I'll have time to redesign my personal page, I'm sure I will try out one of these tools…